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KMID : 0604520090350020111
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Journal of the Society of Cosmetic Scientists of Korea
2009 Volume.35 No. 2 p.111 ~ p.116
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Tissue-cultured Gymnema sylvestre Leaf Extract Enhance Anti-adipogenic Effects through Inhibition of C/EBP- Expression and Lipid Droplet Accumulation
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Park Chang-Min
Joung Min-Seok
Choi Jong-Wan
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Abstract
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Gymnema sylvestre, a traditional India medicine called a ‘Gagaimogouip’ in Korea, has been used to regulate sugar metabolism in patients with diabetes mellitus. First, we induced callus from Gymnema sylvestre leaf and mode extract from cultured callus. In this study, we investigated the anti-obesity effect of tissue-cultured Gymnema sylvestre leaf extract in 3T3-L1 cells. The tissue-cultured Gymnema sylvestre extract inhibited the cytoplasmic lipid accumulation as well as adipogenic differentiation of preadipocytes. The tissue-cultured Gymnema sylvestre extract inhibited insulin-induced predipocyte differentiation through the inhibition of expression of the early adipogenic transcription factor C/EBP-α that regulate adipogenesis. These results indicate that tissue-cultured Gymnema sylvestre extract may be potential natural ingredient for slimming cosmetic products.
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KEYWORD
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Gymnema sylvestre, adipogenesis, C/EBP-α, anti-obesity, callus
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